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KMID : 1144320170490040268
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감염과 화학요법
2017 Volume.49 No. 4 p.268 ~ p.274
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Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-Infected Korean Patients: The Korea HIV/AIDS Cohort Study
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Kim Yong-Chan
Ahn Jin-Young
Kim June-Myung
Kim Youn-Jeong
Park Dae-Won
Yoon Young-Kyung
Song Joon-Young
Kim Shin-Woo
Lee Jin-Soo
Choi Bo-Youl
Choi Yun-Su
Choi Ju-Yeon
Kang Chun
Choi Jun-Yong
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Abstract
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Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea.
Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013.
Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43?17.13).
Conclusions: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.
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KEYWORD
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HIV infection, Hepatitis B virus, Hepatitis C virus, Coinfection
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